产品简介
英文名称
Anti-Abi1 Polyclonal Antibody
宿主
Rabbit
别名
Abelson interactor 1;Abi-1;Abi1;ABI1_HUMAN;Abl binding protein 4;Abl interactor 1;Abl interactor protein 1;Abl-binding protein 4;AblBP4;e3B1;Eps8 binding protein;Eps8 SH3 domain binding protein;Eps8 SH3 domain-binding protein;Eps8-binding protein;Hssh3bp1;Interactor protein AblBP4;NAP1;Nap1 binding protein;Nap1-binding protein;Nap1BP;Spectrin SH3 domain binding protein 1;Spectrin SH3 domain-binding protein 1;SSH3BP;
稀释比例
WB 1:1000-3000.
蛋白分子量
36/43/46/49/52/54/55kDa
Gene ID
10006
保存
Store at -20°C. Avoid freeze / thaw cycles.
储存液
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法
Affinity purification
亚型
IgG
免疫原
A synthetic peptide of human Abi-1
亚细胞定位
Cytoplasm
Swiss Prot
Q8IZP0
背景资料
May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons.
Public Immunogen Range
200-250/508aa
克隆类型
Polyclonal Antibody
交叉反应
Human Rat Mouse
应用
WB
规格
50ul 100ul
 
备注：
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these methods.
实验图
Western blot analysis with Abi1 antibody diluted at 1:2000;Lane:Rat brain,Mouse brain